Poly(lactide-co-glycolide)-based Micro and Nanoparticles for the Controlled Drug Delivery of Vitamins
نویسندگان
چکیده
منابع مشابه
Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents
The effectiveness of anticancer agents may be hindered by low solubility in water, poor permeability, and high efflux from cells. Nanomaterials have been used to enable drug delivery with lower toxicity to healthy cells and enhanced drug delivery to tumor cells. Different nanoparticles have been developed using different polymers with or without surface modification to target tumor cells both p...
متن کاملMicro - and nanoparticles for intestinal drug delivery
Smart dosage form design allows for distinct progresses in selectivity of delivery to the site of action as well as in enhanced transport of the drug across biological membranes. By an optimal choice of carrier type and excipients such systems may offer new therapeutic options such as oral administration of insulin or heparin, where currently no absorption is possible and, on the other hand, lo...
متن کاملPreparation of polylactide-co-glycolide nanoparticles incorporating celecoxib and their antitumor activity against brain tumor cells
BACKGROUND Celecoxib, a cyclo-oxygenase (COX)-2 inhibitor, has been reported to mediate growth inhibitory effects and to induce apoptosis in various cancer cell lines. In this study, we examined the potential effects of celecoxib on glioma cell proliferation, migration, and inhibition of COX-2 expression in vitro. METHODS Celecoxib was incorporated into poly DL-lactide-co-glycolide (PLGA) nan...
متن کاملEffect of Formulation Variables on Preparation of Celecoxib Loaded Polylactide-Co-Glycolide Nanoparticles
Polymer based nanoparticle formulations have been shown to increase drug bioavailability and/or reduce drug adverse effects. Nonsteroidal anti-inflammatory drugs (e.g. celecoxib) reduce prostaglandin synthesis and cause side effects such as gastrointestinal and renal complications. The aim of this study was to formulate celecoxib entrapped poly lactide-co-glycolide based nanoparticles through a...
متن کاملRing-opening polymerization-mediated controlled formulation of polylactide-drug nanoparticles.
We report here a unique method for formulating doxorubicin-polylactide (Doxo-PLA) conjugate nanoparticles, known as nanoconjugates (NCs), through Doxo/(BDI)ZnN(TMS)(2)-mediated [(BDI) = 2-((2,6-diisopropylphenyl)amido)-4-((2,6-diisopropylphenyl)-imino)-2-pentene], chemo- and regioselective polymerizations of lactide (LA) followed by nanoprecipitation. When Doxo/(BDI)ZnN(TMS)(2) was mixed with 1...
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ژورنال
عنوان ژورنال: Current Nanoscience
سال: 2009
ISSN: 1573-4137
DOI: 10.2174/157341309787314566